Periapical lesions develop as sequelae to pulp disease or as a result of a chronic aggression by the presence of pathogenic microorganisms into the root canal. They often occur without any episode of acute pain and are discovered on routine radiographic examination. Microbial invasion of the pulpal tissues occurs either through dental caries, trauma or any developmental tooth anatomy causing pulpal infection and subsequent pulpal necrosis. The necrotic root canal system provides a very favorable environment for the growth of microorganisms inside the root canal system. In the era of minimally invasive dentistry, non-surgical endodontic approach has been highly recommended to promote periapical healing which involves Lesion Sterilization and Repair Therapy (LSRT). The case report series below describes the regression of the periradicular lesion using nonsurgical endodontic treatment (LSRT) that uses a combination of triple antibiotics paste (ciprofloxacin, metronidazole and minocycline). The triple antibiotic paste was used for 3 months. After 3 months, teeth were asymptomatic and were obturated. The follow up cases showed progressive healing of periradicular lesions.
Key words: Lesion Sterilization and Repair Therapy, Triple antibiotic paste.