Journal of AdvancedMedical and Dental Sciences Research

Aim: To investigate the correlation between lipid profile and migraine in patients. Material and methods: A total of 200 patients were included in this study, out of which 100 patients were taken as control having no significant complain under group A and 100 patients having migraine were taken as cases under group B. Detailed history regarding migraine such as type of migraine, symptoms related to aura, duration, type of treatment, if he /she has taken in the past and lipid profile including LDL, HDL, Serum triglycerides, total cholesterol were recorded. Migraine assessment for patients was done. Diagnosis of migraine and categorization of migraine was based on the second International Classification of Headache Disorders (ICHD II). Results: Mean serum total cholesterol was comparatively higher in group B 203.37±6.33 as compared to group A 138.17±4.45. Mean LDL in group A was 87.16±3.42 and 147.37±4.87 in group B. Mean HDL was lower in group B as compared to group A. Mean triglyceride level was 140.36±4.85 and 109.99±3.27 in group B and A respectively. Mean LDL/HDL was 2.30±0.17 and 3.87±0.54 in group A and B respectively. When mean serum total cholesterol, LDL, HDL, triglyceride level and LDL/HDL was compared statistically among group. A and B, the difference was found to be statistically significant in all the parameters as p<0.05 except mean serum HDL level which was found to be statistically insignificant having p>0.05. Conclusion: We concluded that there is a significant association between migraine and visual function defect as well as deranged lipid profile. As our study had a cross-sectional observational design and small sample size so lipid profile derangement in migraine patients has not been studied in detail on all the parameters like VLDL and oxidized LDL cholesterol, total cholesterol and total cholesterol to HDL ratio.