Journal of AdvancedMedical and Dental Sciences Research

Aims: This study's main goal was to investigate how changes in lipid profiles may contribute to breast cancer development in females. Materials and Methods: Using clinical and histological evidence, 100 controls and 100 patients with untreated breast cancer were included in the study. Plasma lipids, including total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglycerides (TG), were analyzed. Aseptic blood samples were taken from the patients and controls, and the lipid profile was estimated using normal operating protocols. Results: In this study, the findings demonstrated that, in comparison to the control group, the levels of T-C, LDL-C, and T-C/HDL-C ratio were considerably higher in each of the four stages of breast cancer. There was no change in the levels of VLDL or HDL-C. When comparing the findings from different stages, the lipid profile and T-C:HDL-C ratio indicated negligible differences. Comparing the results between primiparity (one birth) and multiparity (2–5 births), the lipid profile and T-C:HDL-C ratios in relation to parity in breast cancer patients were not substantially altered (Table 1). the patients with breast cancer were divided into three age groups. There was no discernible difference in the T-C:HDL-C ratios or the lipid profile values between the three groups' results (Table 2). Conclusions: One reason for changes in the levels of the lipid profile could be the onset of breast cancer.