Journal of AdvancedMedical and Dental Sciences Research

Background:Labor is a multifaceted physiological process that culminates in the delivery of the fetus after a painful contraction of the uterus produces cervical dilatation and effacement. The present study compared Drotaverine Hydrochloride &Valethamate Bromide in augmentation of labour. Materials & Methods:84 primigravida women in established labourwere divided into 2 groups of 42 each. Patients in group I were given 40mg Drotaverine Hydrochloride IM every two hourly and in group II were given 2ml (8mg) Valethamate Bromide. A vaginal examination was performed to monitor the development of labor. Records were kept on parameters like the length of the second stage of labor, the delivery method, the outcome for the newborn, and medication side effects. Results: The age group 18-22 years had 28 subjects in group I and 26 in group II and 23- 27 years had 16 in group I and 18 in group II. Active phase was 3.6 hours in group I and 4.8 hours in group II, second stage was 35.2 minutes in group I and 39.6 minutes in group II and third stage was 6.4 minutes in group I and 6.7 minutes in group II. The mode of delivery was NVD in 30 in group I and 32 in group II, forcep in 6 and 3, vacuum in 4 and 3 and LSCS in 2 and 4 in group I and group II respectively. The side effects were tachycardia in 1 and 0, xerostomia in 4 and 2, headache in 2 and 5, and hypotension in 3 and 2 patients in group I and group II respectively. The difference was non- significant (P> 0.05). Conclusion: In terms of augmentation of labor, drotaverine hydrochloride is reported to be superior to valethamate bromide.