Journal of AdvancedMedical and Dental Sciences Research

Background: Polycystic Ovarian Syndrome (PCOS) stands out as the prevailing endocrine disorder among women in their reproductive years. PCOS is characterized by chronic anovulation, menstrual irregularities, hyperandrogenism, polycystic ovaries, and metabolic syndrome. The objectives of this study are to explore the clinical, biochemical, and hormonal profiles in individuals with PCOS and establish correlations with those of normal subjects.Methods: We are conducting a prospective case-control study involving 100 women aged 18-30 years. This study comprises two groups: 50 participants diagnosed with Polycystic Ovary Syndrome (PCOS) and an equal number of individuals in the control group.Results: Among individuals with Polycystic Ovary Syndrome (PCOS), 92% exhibited menstrual irregularities, with oligomenorrhea being the most prevalent presentation. Infertility was observed in 52%, and 53% displayed hirsutism. Comparatively, PCOS individuals showed statistically significant differences (P value <0.001) in mean BMI, waist-to-hip ratio, LH level, LH:FSH ratio, total testosterone, fasting insulin, and total cholesterol when compared to the control group. The mean LH was 15.44 ± 7.09 in the PCOS group and 9.92 ± 4.55 in the control group.Conclusion: The majority of individuals with Polycystic Ovary Syndrome (PCOS) exhibited characteristics such as oligomenorrhea, hirsutism, elevated BMI, and an increased waist-hip ratio. PCOS cases also demonstrated statistically significant elevations in mean LH, LH:FSH ratio, testosterone, and fasting insulin levels compared to non-PCOS individuals.