Journal of AdvancedMedical and Dental Sciences Research

Background: Propofol causes dose dependent reductions of cerebral metabolic rate and blood flow so coupling of flow metabolism is maintained. The present study was conducted to compare sevoflurane (inhalational) anaesthesia and prop of ol (TIVA) based anaesthesia. Materials & Methods: 90 patients aged 18-65 years were divided into two groups. Group I received inhalational sevoflurane induction for 1 minute. Group II patients were induced with propofol i.v 2-2.5mg/kg. Intraoperative maintenance was done with multistep propofol infusion (8mg/kg/hr -3mg/kg/hr) via infusion pump.Parameters such as MAP and recovery profile was recorded. Results: Group I comprised of 22 males and 23 females and group II had 20 males and 25 females. Time of spontaneous eye opening was 9.4 minutes in group I and 13.1minutes in group II, time to verbal communication was 12.5 minutes in group I and 15.3 minutes in group II and time to mental orientation was 16.2 minutes in group I and 20.6 minutes in group II. The difference was significant (P< 0.05). The mean MAP (mmHg) in group I and II was 102.5 and 104.1, before induction was 100.2 and 99.7, after induction was 91.0 and 90.4, 5 minutes after intubation was 95.4 and 93.0, at 15 minutes was 102.1 and 99.8, at 30 minutes was 102.0 and 101.3 and at 45 minutes was 102.9 and 101.1 respectively. The difference was non- significant (P> 0.05). Conclusion: Sevoflurane is better thanpropofol in terms of faster induction and rapid recovery.