Journal of AdvancedMedical and Dental Sciences Research

Background: Insulin resistance is accepted to be a major risk factor in the etiology of type 2 diabetes mellitus, hypertension, dyslipidemia, atherosclerotic vascular disease, and may be a risk factor for coronary heart disease and stroke. The present study compared IR levels newly diagnosed T2DM and normal subjects. Materials & Methods: 90 subjects were divided into 3 groups. Group I was subjects with NGT, group II was hyperinsulinemia with normal blood glucose tolerance (HINS) and group III was newly diagnosed T2DM. Oral glucose tolerance test (OGTT) was administered to all. Assessment of weight, BMI, SBP, DBP, TG, LDL, HDL, TC and HOMA- IR was performed in all groups. Results: Group I had 15 males and 15 females, group II had 13 males and 17 females and group III had 12 males and 18 females. The mean SBP (mm Hg) was 126.0, 122.6 and 128.8, DBP (mm Hg) was 76.2, 82.4 and 78.4, BMI (Kg/m2) was 24.3, 25.3 and 27.4, waist (cm) was 76.2, 88.4 and 92.2, TG (mmol/L) was 1.26, 2.08 and 1.78, LDL (mmol/L) was 2.56, 2.96 and 3.14, HDL (mmol/L) was 1.82, 1.54 and 1.08, TC (mmol/L) was 4.92, 5.28 and 4.76, Glu 0 (mmol/L) was 4.14, 4.76 and 5.26, Glu 120 (mmol/L) was 5.46, 6.23 and 13.8 and HOMA- IR was 0.96, 2.58 and 3.04 in group I, II and III respectively. The difference was significant (P< 0.05). Conclusion: Insulin resistance existing in newly diagnosed T2DM, subjects with normal glucose tolerance and subjects with hyperinsulinemia with normal blood glucose tolerance.