Journal of AdvancedMedical and Dental Sciences Research

Aim: This study was carried out to assess the serum uric acid levels in essential hypertension and its correlation with the severity and known duration of hypertension. Material and methods: The observational and case control study was conducted in the Department of Biochemistry. A total of 140 patients were taken into the study with an equal proportion of cases and controls of 1:1. 70 patients were taken as cases that were known cases of essential hypertension irrespective of treatment status and were graded into different stages of hypertension as per JNC VII guidelines. Results: Out of 70 cases, 33 (47.14%) were male patients and 37 (52.86%) were female patients. Mean BMI in cases was 24.04 kg/m2 whereas it was 24.37 kg/m2 in case of controls which was comparable among the two groups. Overall mean systolic BP in cases was 170 mmHg and mean diastolic BP was 103 mmHg. Overall, 23 (32.86%) patients were grouped in stage 1. 39(55.71%) patients in stage 2 and 8 (11.43%) patients in isolated systolic hypertension (ISH). Maximum patients were in stage 2 among both males (60.60%) and females (51.35%). Mean systolic and diastolic blood pressure in stage 1 was 147. 22 mmHg and 95.21 mmHg. In stage 2 it was 187.07 mmHg and 113.11mmHg respectively. In ISH systolic BP was 147.85 mmHg and diastolic BP was 86.12 mmHg. Among cases the range of serum uric acid level in males was 1.90-11.70 with mean value of 7.31 whereas in females range of serum uric acid level was 1.31-10.80 with mean value of 7.14. Overall mean value of cases was 7.22. Overall mean serum uric acid levels in stage 1 hypertension was 6.52 mg/dl, in stage 2 it was 7.83 mg/dl and in ISH it was 6.22 mg/dl. Among patients with less than 5 years of duration of HTN, serum uric acid levels in stage 1 were 6.29 mg/dl, in stage 2 it was 6.61 mg/dl and in ISH the levels were 5.40 mg/dl. Among patients with greater than 5 years of duration of HTN, serum uric acid levels in stage 1 were 6.57 mg/dl, in stage 2 it was 8.04 mg/dl and in ISH the levels were 6.57 mg/dl. Conclusion: we concluded that the serum uric acid is significantly elevated in hypertensive as compared to normotensive individuals.