Journal of AdvancedMedical and Dental Sciences Research

Background: The diseases of upper gastrointestinal tract are highly prevalent in population and patients present with varied symptoms such as dysphagia, pain while eating, nausea, vomiting, dyspepsia, & loss of weight. The present study was conducted to histomorphological spectrum of upper gastrointestinal lesions. Materials & Methods: 58 upper GIT endoscopic biopsies of both genders were recruited. All the biopsy samples were fixed in 10% buffered formalin, followed by conventional tissue processing, cut at 3-4-micron thick sections, stained with Haematoxylin and Eosin. Periodic Acid Schiff (PAS) stain and Acid-Fast stains were performed. Results: Out of 58 cases, 32 were of males and 26 were of females. There were 12 neoplastic and 46 non- neoplastic lesions. Maximum lesions were seen in duodenum (34) followed by stomach (18) and esophagus (6). There was correlation of endoscopic and histopathological findings of oesophageal lesions (P< 0.05). Conclusion: Upper gastro- intestinal endoscopy is an effective investigative modality to assess patients with upper gastrointestinal symptoms, and to obtain representative biopsies.