Journal of AdvancedMedical and Dental Sciences Research

Background: Pulmonary artery hypertension is a hemodynamic and pathophysiological condition defined as an increase in mean pulmonary artery pressure (mPAP) > 25 mm Hg at rest and > 30 mm Hg during exercise. The present study was conducted to assess thyroid function in idiopathic pulmonary hypertension. Materials & Methods: 82 patients of idiopathic pulmonary hypertension of both genders were enrolled. The evaluation of RV dysfunction was done by both a thorough physical examination and echocardiographic examination using a 2 MHz GE S4 Probe. The thyroid markers (TSH, thyroxine [T4], and triiodothyronine [T3]) were assessed by electrochemiluminescence. The functional capacity was studied using the SMWT. Results: Out of 82 patients, males were 50 and females were 32. The meanT3 was 123.8n/dl, T4 was 8.9mcg/dl, TSH was 4.1mIU/ml, PAP was 50.4mmHg, CVP was 9.5mmHg, RVEDD was 3.7 cm, TAPSE was 1.9 mm and SMWT was 370.4 m. The mean T3 level of TAPSE >15 mm was 125.2, T4 was 8.5 and TSH was 4.1, <15 mm of T3 was 113.2, T4 was 8.3 and TSH was 4.8. The difference was significant in T3 (P< 0.05). The mean T3, T4 and TSH level of RVEDD > 3cm and < 3 cm was 121.4 and 124,7, 8.7 and 9.9 and 4.5 and 3.4 respectively. The difference was significant in RVEDD (P< 0.05). The mean T3, T4 and TSH level of SMWT > 200 m and < 200 m was 130.4 and 119.2, 9.0 and 8.6 and 3.6 and 5.2 respectively. The difference was significant in SMWT (P< 0.05). The mean T3, T4 and TSH level of CVP >5 mm Hg and < 5 mm Hg found to be 125.7 and 130.2, 8.7 and 10.6 and 4.5 and 3.9 respectively. Conclusion: Idiopathic pulmonary hypertensionis associated with subclinical hypothyroidism and low patient functional capacity.