Journal of AdvancedMedical and Dental Sciences Research

Background: Prostatic adenocarcinoma is the most prevalent form of cancer in men and the second leading cause of cancer death in the United States. The present study evaluated the role of Prostein in the diagnosis of prostate carcinoma. Materials & Methods: 65 prostate samples obtained from general surgery department suspected of prostate carcinoma. Samples were fixed in buffered formalin, followed by paraffin embedding and stained with hematoxylin and eosin (H and E). Diagnosis of samples were performed. Immunohistochemistry (IHC) was performed on Ventana automated stainer. Results: Age group 30-40 years had 14, 50-60 years had 40 and >60 years had 11 patients. The difference was significant (P< 0.05). Diagnosis was normal epithelium in 12, benign prostate hyperplasia (BPH) in 20, primary adenocarcinoma in 25, metastatic adenocarcinoma in 5 and HGPIN in 3. The difference was significant (P< 0.05). Conclusion: Prostein had specificity of 100% in differentiating various prostatic carcinoma hence, can be used in prostate lesions.