Journal of AdvancedMedical and Dental Sciences Research

Aim: To study the role of serum protein fractions as Early Index of Clinical Recovery in Pulmonary Tuberculosis patients. Methods: This cross-sectional study was done the Department of chest and T.B. A total of 80 subjects aged between 19 and 49 years were conveniently recruited for this study. 40 were clinically confirmed PTB subject with no HIV nor malaria co-infections. They were further sub-divided into TB subjects on ATT 20 and drug naive TB subjects 20. The remaining were 40 aged matched apparently healthy controls. Results: The results showed that BMI (kg/m2) in drug naive TB subjects (19.36 ± 2.76) and in the TB subjects on ATT (20.41 ± 2.91) was significantly lower when compared to control subjects (24.69 ± 3.16) (p ¼ 0.000). Similarly, waist and hip circumferences (cm) of the drug naive TB subjects (50.23 ± 1.45, 70.69 ± 2.11) and the TB subjects on ATT (51.15 ± 2.99, 70.57 ± 2.76) were significantly lower when compared to control subjects (52.35 ± 4.57, 72.34 ± 3.55) (p ¼ 0.04, 0.03). However, the mean value of WHR in drug naive TB subjects (0.73 ± 0.05) and in TB subjects on ATT (0.75 ± 0.06) were not statistically significant when compared to control subjects (0.74 ± 0.07) (p ¼ 0.27). Also, the mean weight (kg) of TB subjects on ATT (58.28 ± 4.71) when compared with that of the drug naive TB subjects (51.58 ± 10.61) was not statistically significant (p ¼ 0.12). The results showed that the mean serum total protein levels (g/dl) in TB subjects on ATT (8.93 ± 1.75) and in the drug naive TB subjects (9.13 ± 1.88) were significantly higher when compared with the control subjects (7.89 ± 0.98) (p ¼ 0.003). Mean serum globulin (g/dl) level in TB subjects on ATT (3.52 ± 1.63) was significantly lower when compared to their counterparts not on ATT (6.34 ± 1.97) (p ¼ 0.000). Conclusion: We concluded that the BMI was found to be significantly lower in both drug naive PTB subjects and in PTB subjects on ATT when compared with the control subjects.