Journal of AdvancedMedical and Dental Sciences Research

Background: Primary hepatic malignancies in children comprise about 0.5–2% of all solid tumors in children of which hepatoblastoma is the most common with an incidence of 1.5 cases per million children less than 18 years of age worldwide. The present study was conducted to assess clinico- pathological profile of hepatoblastoma. Materials & Methods: 24 children of Hepatoblastoma (HB) of both genders were included in our study. PRETEXT staging was performed with contrast computed tomography (CT). Histological data on biopsy and/or resection specimens were analyzed. Results: Jaundice was seen in 6, abdominal distention in 2, vomiting in 4 and mass abdomen in 2. Duodenal sepsis was seen in 2, fever at 1 month in 1 and uneventful in 2 cases. The difference was significant (P< 0.05). Pretext stage I was seen in 8, II in 7, III in 4 and IV in 5, histology was epithelial in 16 and mixed epithelial & mesenchymal in 8, risk was high in 9 and standard in 15, treatment given was nil in 4, Plado 1 cycle in 2, Plado 2 cycle in 1, Plado 4 cycle in 5, Plado 6 cycle in 4 and Plado with surgery in 8 cases. The difference was significant (P< 0.05). Conclusion: Pretext stage II was less commonly involved in children diagnosed with hepatoblastoma.