Journal of AdvancedMedical and Dental Sciences Research

Traditionally refer vascular and hemodynamic disorders at mother to risk factors of premature detachment of normally located placenta, such as, generalized dysfunction of an endothelium which occurs in the uteroplacental pool, developing at a gestosis and various somatic pathology. Research objective was studying of diagnostic value of definition in blood of a number of markers of a functional condition of an endothelium at women with the premature bursting amniotic waters (PBAW). 72 patients were examined. The main group was made by 48 pregnant women of the full-term with PBOW in the absence of biological readiness for childbirth. The blood analysis on the maintenance of markers of the endothelium dysfunction (ED) was conducted: thrombomodulin, soluble molecules of adhesion (sICAM-1 and sVCAM-1), Villebrand's factor, fibronectin. Results of a research showed on increase in content of thrombomodulin, sICAM-1, Villebrand's factor, fibronectin in a maternal blood-groove at PIOV what demonstrates activation and stimulation of endotheliocytes at this pathology. Thus, determination of content in blood of a number of markers of ED, is diagnostically and predicatively significant in diagnostics of PBOW at pregnant women.