Background: All parts of the eye may be infected by bacteria, fungi, parasites, or viruses. Anti-infectives such as antibiotics (ATB), antiseptics, antifungals, anti-helminths or antivirals can be used depending on the type of infection. The aminoglycosides gentamicin and tobramycin are well established as first-line therapy for external ocular infections, and possess a broad spectrum of activity against Aim of the study: To compare efficacy of Topical Ofloxacin and Gentamicin for external ocular infection. Materials and methods: The present study was conducted in the Department of Ophthalmology of the Medical institution. The ethical clearance for the study was approved from the ethical committee of the hospital. For the study, a total of 80 patients with suspected external ocular bacterial infection were selected. A detailed informed consent was obtained from the patients. Patients who were allergic to any of the drug or constituents of the medication were removed from the study. The patients were randomly grouped into two groups, Group 1 and Group 2. Subjects in group 1 were given topical Ofloxacin for application on the eye with external ocular infection. Subjects in group 2 were given topical Gentamicin for application on the eye with external ocular infection. One drop of the medication was applied to the affected eye(s) six times daily (every 2 to 4 hours) for 2 days (day 1 and day 2) and then four times daily for the next 8 days (day 3 to day 10). Results: There were total of 40 patients in each group. Number of male patients in group 1 was 25 and in group 2 was 22. Number of female patients in group 1 was 15 and in group 2 was 18. In group 1, clinical improvement was seen in 44 patients and microbiological improvement was noticed in 43 patients. In group 2, clinical improvement was seen in 43 patients and microbiological improvement was noticed in 44 patients. Conclusion: Within the limitations of the present study, it can be concluded that Gentamicin and Ofloxacin are highly effective in treatment of external ocular infections.
Keywords: Gentamycin, Ofloxacin, ocular infection.