Background: Acute poisoning by pesticide compounds is a major global clinical problem. The present study was conducted to evaluate histopathological changes of liver in agricultural poisoning. Materials & Methods: The present study was conducted on 70 autopsies of liver of both genders. Type of poison was confirmed by toxicological evaluation reports. During Autopsy detailed internal and external examinations were done and random portion of Liver were collected for histological examination. Results: Maximum cases were of age group 25- 35 years which comprised of 28 males and 4 females followed by 35-45 years (20), >45 years (12) and 15-25 years (6). Major poison was organophosphorous seen in 35 cases followed by Aluminium and zinc phosphate in 18, Pyrethrin compounds in 10 and Unknown in 7 cases. Group I liver changes was seen in 9, group II in 23 and group III in 38 patients. The difference was significant (P < 0.05). Conclusion: Authors found that maximum cases were of group III liver changes and age group 25- 35 years. There was male predominance.
Key words: Liver, Aluminium, Zinc phosphate