Background: Diabetes Mellitus (DM) is a syndrome characterized by a state of chronic hyperglycemia. The present study compared different hypoglycemic agents in type II DM patients. Materials & Methods: The present study was conducted on 90 patients of type II diabetes mellitus of both genders. Baseline investigations such as fasting blood sugar (FBS), post prandial blood sugar (PPBS) and HbA1c were noted. Patients were divided into three groups, Group I using biguanides + sulfonylureas (SU), Group II on biguanides+ thiazolidinediones and Group III using biguanides+ dipeptidyl peptidase inhibitors (DPI). Results: Mean fasting FBG (mg/dl) in group I was 178.2, in group II was 176.4 and in group III was 174.8, FBG after 6 months in group I was 126.4, in group II was 146.2 and in group III was 150.2. Post prandial blood sugar (PPBS) baseline in group I was 266.2, in group II was 260.4 and in group III was 264.2, PPBG after 6 months in group I was 184.6, in group II was 210.4 and in group III was 204.6. There was significant reduction in blood glucose level in group I compared to group II and group III (P< 0.05). The most common ADR was hypoglycemia seen 4 in group I, 1 in group II and 2 in group III followed by nausea 2 in group I, 1 in group II and 4 in group III and vomiting 3 in group I and 3 in group III. The difference was significant (P< 0.05). Conclusion: Authors found that combination of biguanides + sulfonylureas was effective in lowering down blood glucose level in type II DM patients.
Key words: blood glucose, diabetes, sulfonylureas.