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Volume 7 Issue 11 (November, 2019)

Original Articles

Relationship between insulin metabolic disorders and pediatric stress hyperglycemia
Purva Jain, Harshita Shah

Background: Stress hyperglycemia (SH) commonly occurs during critical illness in children, even in those with previously normal glucose homeostasis. Based on the premise that SH during critical illness is possibly harmful, tight glucose control (TGC) to normalize blood glucose (BG) concentrations has emerged as a rational but unproven therapy to improve outcomes in critically ill children. Aim of the study: To study relationship between insulin metabolic disorders and pediatric stress hyperglycemia. Materials and methods: The present study was conducted in the Department of Pediatrics, MGM Medical College, Navi Mumbai, Maharashtra, India. For the study, we selected 70 patients admitted in the ward of Department of Pediatrics. Blood glucose greater than 200 mg/dl was considered as hyperglycemia. A written informed consent was obtained from the subjectís parents or guardians. At the admission, we recorded patientís height, weight, BMI, and blood pressure. After 12 hours of fasting fading blood sugar, triglyceride, cholesterol levels and insulin levels were measured. A single dose of 1.75 g/kg of glucose was administered to the subjects and blood glucose was determined after 2 hours. Results: A total of 70 patients were included in the study. The mean age of the subjects was 9.32 years. The mean weight of the subjects was 25.65 kg, mean height is 1.16 m, mean BMI is 20.65 and mean systolic blood pressure is 110.87 mmHg. Glucose tolerance impairment was seen in 26 patients, BMI> 95th percentile was seen in 19 patients, systolic blood pressure >95th percentile was seen in 13 patients, HDL < 5th percentile was seen in 14 patients, triglycerides >95th percentile was seen in 11 patients, and insulin resistance was seen in 39 patients. Conclusion: According to results of this study, this can be concluded that the risk of progression of stress hyperglycemia to diabetes mellitus is high. Keywords: Diabetes mellitus, stress hyperglycemia, insulin resistance

 
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