Journal of AdvancedMedical and Dental Sciences Research

Background: Precancerous disorders of oral mucosa are the pathologic entities that have malignant transformation risk at different ratios. Results from the past literature in assessment of malignant disorders have shown that various substances alter quantitatively in the serum during tumor development and are referred to as tumor markers. Hence; we assess the alterations occurring in serum lipid profile of the subjects with premalignant disorders of the oral cavity.Materials & methods:The present study included assessment of serum lipid profile of the patients with oral precancerous disorders. A total of 50 patients were included in the present study. Patients with oral submucous fibrosis and oral leukoplakia were categorized as affected by premalignant disorders. Age and gender matched 50 healthy subjects were included in the study group. All the patients were called in the morning and fasting blood samples were obtained under septic conditions. All the blood samples were sent to pathology department for the estimation of serum lipid profile. All the results were recorded in Microsoft excel sheet and were assessed by SPSS software.Results:Mean serum lipid profile of the patients of the study group were significantly lower than subjects of the control group.Conclusion:Premalignant changes in the oral cavity also produce alterations in the mean serum lipid profile of the patients. Key words: Lipid, Oral Premalignant, Serum.