Journal of AdvancedMedical and Dental Sciences Research

Background: Laparoscopic cholecystectomy has established itself firmly as the “gold standard” for the treatment of gallstone disease. The present study was conducted to determine the role of tranexamic acid in controlling blood loss in laparoscopic cholecystectomy. Materials & Methods: The present study was conducted in the department of general surgery on 40 patients who complaint of cholelithiasis and underwent laparoscopic cholecystectomy. Patients were divided into 2 groups. Group I received intravenous dose 20 mg/kg of tranexamic acid at induction of anesthesia. Group II did not receive any tranexamic acid. Medical history such as any drug intake ie anticoagulants, antifibrinolytics and antiplatelets were taken. Patients were subjected to estimation of hemoglobin (Hb), TLC, DLC, CT FBS, liver function tests, urine complete examination, and abdominal Ultrasonography (USG). Results: Out of 40 patients, group I had 20 and group II had 20 patients. The difference was non- significant (P-1). Group I had 7 males and 13 females while group II had 6 males and 14 females. The difference was significant (P-0.02). The mean postoperative hospital stay, drain fluid Hb, drain fluid hematocrit, drain fluid output, mean pulse rate at the start of surgery, mean pulse rate 24 h after surgery, and mean change in Hb in both groups were not significant (P>0.05). Common comorbidities in patients was smoking (group I-1, group II-2), hypertension (group I-2, group II-3), diabetes (group I-1, group II-2), alcoholic (group I-3, group II-4) and drug addiction (group I-1, group II-1). The difference was non- significant (P>0.05). Conclusion: Laproscopic cholecystectomy is widely used surgical procedure in cases of cholelithiasis. The blood loss is can be managed by use of tranexamic acid. However, the difference in both group was non- significant.
Key words: Hypertension, Laproscopic cholecystectomy, Tranexamic acid.

Corresponding author: Dr. Abu Noaman, Senior Resident, Department of General Surgery,  Rama Medical College, Hospital & Research Centre, Ghaziabad, U.P., India

This article may be cited as: Hasan A, Noaman A. Efficacy of Tranexamic Acid in Laproscopic Cholecystectomy. J Adv Med Dent Scie Res 2017;5(12):74-77.