Journal of AdvancedMedical and Dental Sciences Research

Background:Preeclampsia is a serious complication of pregnancy characterized by high blood pressure (hypertension) and signs of damage to another organ system, most commonly the liver and kidneys. The present study was conducted to evaluate inflammatory markers in preeclampsia. Materials & Methods:90 females with third trimester of pregnancywere divided into 3 groups of 30 each. Group I were mild preeclamptic, group II were severe preeclamptic and group III were controls. Body mass index (BMI) and mean arterial pressure, serum IL-10 and TNF-α concentrations were measured. Results: The mean gestational age in group I subjects was 34.2 weeks, in group II was 33.1 weeks and in group III was 33.6 weeks. The mean BMI was 30.5 Kg/m2 in group I, 29.2 Kg/m2 in group II and 29.7 Kg/m2 in group III. The difference was non- significant (P>0.05). In group I, group II and group III, the mean IL-10 was 9.7 pg/mL, 12.3 pg/mL, 4.8 pg/mL. TNF-α was 30.4 pg/mL, 65.2 pg/mL and 6.9 pg/mL in group I, group II and group III respectively. hs-CRP was 9.6mg/L, 12.1 mg/L, and 4.3 mg/L in group I, group II and group III respectively. Urinary protein level was 1390.4 mg/24 hours, 4124.6 mg/24 hours, and 136.8 mg/24 hours in group I, group II and group III respectively. The mean MAP was 114.2 mm Hg, 136.4 mm Hg, and 84.2 mm Hg in group I, group II and group III respectively. The difference was significant (P< 0.05). Conclusion: Inflammatory markers play a significant role in the pathophysiology of preeclampsia, contributing to endothelial dysfunction, vascular injury, and maternal systemic inflammation.Preeclamptic women have high levels of hs-CRP, TNF-α, and IL-10, which suggests that these markers can be used identifying the severity of preeclampsia.