Journal of AdvancedMedical and Dental Sciences Research

Aim:Assessing the effectiveness of two Antihypertensive medications in managing pregnancy-induced hypertension. Materials and method:This study was done in the Department of Pharmacology. This research included all pregnant women who had a diastolic blood pressure (DBP) higher than 100 mm Hg on at least two separate occasions, with a time interval of 4 hours, after reaching 20 weeks of gestation.A total of 200 patients diagnosed with PIH were randomly assigned to two groups, with 100 patients in each group. Following informed written permission, Group A was administered Nimidipine 30 mg every 8 hours, whereas Group B got Nifedipine 10 mg every 8 hours in an alternating manner with equivalent distribution. The groups were also separated into two subgroups: one with diastolic blood pressure (DBP) between 100-109 mm Hg, and another with DBP over 110 mm Hg. The age, parity, pre-treatment risk factors that impact the mother and fetal outcome, non-stress test (NST), and extra medicines such as magnesium sulfate (MgSO4) and phenobarbital utilized on the patients in both groups were carefully matched. Results:In Group A, the highest number of instances occurred between 37-40 weeks of gestation, whereas in Group B, it was between 33-36 weeks. The diastolic blood pressure upon presentation is statistically comparable between the two groups, with a p-value of 0.31. The incidence of non-proteinuric and proteinuric conditions is similar in both groups (p=0.43). The Apgar scores at 1 and 5 minutes are statistically similar between the two groups (p>0.05). Both groups exhibit similar levels of control in terms of systolic and diastolic blood pressure. Group A had a low incidence of adverse effects, such as headache, flushing, and hypotension, affecting around 3% of participants. The perinatal outcomes in both groups were similar, with a 95% probability of babies being allowed to go home in Group A and 87% in Group B, indicating comparable results. Conclusion:Nimodipine is a viable substitute for Nifedipine in managing hypertension during pregnancy due to its safety, efficacy, and few adverse effects.Due to its higher cost compared to Nifedipine in countries like India, Nifedipine remains the preferred first medication.