Journal of AdvancedMedical and Dental Sciences Research

Background:Pre-eclampsia is a pregnancy complication characterized by high blood pressure and signs of damage to another organ system, often the kidneys. The present study was conducted to assess risk factors for cardiopulmonary dysfunction in early-onset severe pre-eclampsia. Materials & Methods:78 patients with severe pre-eclampsia diagnosed at less than 34 weeks of pregnancywho received expectant management to prolong theirpregnancywere divided into 2 groups based on cardiopulmonaryfunction. Group I was patients with normal cardiopulmonary function and group II was patients with decompensatory cardiopulmonary function. The clinical characteristics of patients in the two groups were compared. Results: Fetal growth restriction was seen in 16 in group I and 22 in group II. 12 patients in group I and 15 in group II required intravenous antihypertensivemedications. The mean alanine aminotransferase level was 25.2IU/L in group I and 30.4IU/L in group II. The mean creatinine level was 57.3μmol/L in group I and 78.1μmol/L. Platelet count was 170.2cells/μL in group I and 165.2cells/μL. The mean proteinuria was 5.2g/24 h in group I and 8.4g/24 h in group II. The mean plasma albumin was 27.4g/L in group I and 25.3g/L in group II. The difference was significant (P< 0.05). The serumcreatinine (P-0.04), increased proteinuria(P-0.05), and ascites (P- 0.01) were factors that demonstrated associations with decompensation of cardiopulmonary function. Conclusion: Ascites and renal insufficiency were linked to cardiopulmonary dysfunction. More medical attention should be given to ascites while managing early-onset severe pre-eclampsia.