Journal of AdvancedMedical and Dental Sciences Research

Aim:Anemia is a worldwide public health issue that affects both developing and industrialized nations. The present study was conducted to find association of iron deficiency anemia with Hba1c levels in non-diabetics and effect of iron therapy on Hba1c levels. Methodology: 84 patients with iron deficiency anemia were assessed for haemoglobin, HbA1c, serum ferritin, serum iron, total iron binding capacity (TIBC), mean corpuscular haemoglobin (MCH), mean corpuscular volume (MCV), mean corpuscular haemoglobin concentration (MCHC), blood urea and serum creatinine. Patients received iron supplementation for three months in the form of oral ferrous sulphate (325 mg per tablet), with dosages appropriate for the severity of their anemia. The HbA1c level was evaluated before and after iron therapy. Serum iron and TIBC were measured using the ferrozine/MgCO3 technique. A method based on chemiluminescence was used to assess serum ferritin. Results: The age group ≤30 years had 5, 31-40 years had 18, 41-50 years had 26 and 51-60 years had 35 patients. The difference was non- significant (P> 0.05). There were 24 cases of mild, 50 cases of moderate and 10 cases of severe anemia. The difference was significant (P< 0.05). The mean hemoglobin at baseline and at 3 months was 9.26 and 11.12, serum iron was 20.4 and 60.3, TIBC was 340.1 and 348.5, serum ferritin was 8.12 and 46.2 and HbA1c was 5.27 and 5.12 respectively. The difference was significant (P< 0.05). At baseline HbA1c had negative excellent correlation with Hb (-.752) while after iron supplementation there was decrease in HbA1c levels and increase in Hb levels. HbA1c and hemoglobin at 3 months showed negative moderate correlation with Pearson’s coefficient value being -0.55 (p<0.001). This signifies that as the value of Hb increases there is a moderate decrease in HbA1c. Conclusion: A significant correlation between iron deficiency anemia and elevated HbA1C level in non- diabetics was found. HbA1C increases with the severity of anaemia and vice versa. The decreased erythrocyte indices, decreased erythrocyte life span, and altered morphology play a significant role.