Journal of AdvancedMedical and Dental Sciences Research

Background: The most typical clinical signs of spontaneous miscarriage are vaginal bleeding and the spontaneous ejection of an embryo or fetus from the uterus. The present study assessed Mifepristone's efficacy in induction of first-trimester miscarriage. Materials & Methods: 96 patients with first-trimester miscarriage prior to the 14th week of gestation were given repeatable doses of 800 mcg misoprostol vaginally. Parameters such as type of miscarriage, gravidity, parity, number of doses, time of drug administration, and side effects were recorded. Results: Out of 95 cases, 74 had successful induction and 21 had unsuccessful induction. The difference was significant (P< 0.05). The time from the previous delivery was 3.25 years and 3.85 years in successful and in unsuccessful induction respectively. The number of miscarriages was 1 in 63 and 13 respectively, and >2 in 12 and 8 respectively, missed abortion was seen in 65 and 14 and blighted ovum in 18 and 6 respectively. Previous surgical interventions on uterus was seen in 10 and 7 in successful and unsuccessful induction respectively. The difference was significant (P< 0.05). Conclusion: First-trimester abortion can be effectively and safely treated with pharmacological induction with Misoprostol.