Journal of AdvancedMedical and Dental Sciences Research

Aim: To compare the effects of 1% chloroprocaine and 1% chloroprocaine with clonidine during spinal anaesthesia procedures. Material and methods: 100 total ASA Patients in grades I or II who are between the ages of 18 and 55, of either sex, and who weigh between 40 and 65 kg who are scheduled for elective infraumbilical procedures lasting less than 60 minutes. Patients having a history of local anaesthetic allergy or intolerance, refusal, uncooperation, infection at the site, coagulopathy or bleeding diathesis, cardiac, neurological, hepatic, or renal illness, pregnancy, or lactation were excluded from the research. Group C (n=50): 30 mg of 1% Chloroprocaine with 0.2 ml Normal saline. Group CC (n =50): 30 mg of 1% Chloroprocaine with 30 mcg Clonidine (0.2 ml). Results: With the addition of clonidine (GroupCC), the onset of sensory and motor block occurred more quickly (P<0.05). In group CC, more patients (64% vs. 32%; P <0.05) achieved the T6 T-9 level block than in group C. In comparison to group C, group CC showed longer durations of motor block, quicker time to mobilise, and post-operative analgesia. In both group C and group CC, there were no significant variations in PR and all three blood pressure measures (P>0.05). Conclusion: In short-duration nursery procedures, the intrathecal addition of preservative-free Clonidine (30mcg) to preservative-free 1% Chloroprocaine produces good spinal anaesthesia with extended analgesic duration and hemodynamic stability.