Journal of AdvancedMedical and Dental Sciences Research

Background: Primary open angle glaucoma (POAG) is the most common form of the disease worldwide. The present study compared LatanoprosteneBunod, Timolol Maleate, and latanoprost ophthalmic solutions in lowering intraocular pressure in open-angle glaucoma. Materials & Methods: 90 patients of open-angle glaucoma of both genderswere divided into 3 groups of 30 each. In group I, patients were prescribed latanoprost. In group II, patients receivedlatanoprostenebunod, and in group III, patients were prescribed timolol maleate.IOP was measured using a topical proparacaine 0.5% as the local anesthetic. Blood pressure and heart rate were measured immediately before IOP measurements. Results: The mean IOP was 24.8 mm Hg in group I, 23.6 mm Hg in group II and 24.2 mm Hg in group III. Heart rate was 77.4 bpm in group I, 76.8 bpm in group II and 77.2 bpm in group III. The difference was non- significant (P> 0.05). Adverse events were conjunctival hyperemia in 2, 0 and 1, eye pain in 2, 1 and 1, foreign body sensation in eyes in 1, 1 and 0, dry eyes seen in 4, 4 and 3, eye irritation in 2, 2 and 1 in group I, group II and group III respectively. The difference was non- significant (P> 0.05). Conclusion: Latanoprostenebunod was more effective than latanoprost and timololin reducing IOP in patients with open-angle glaucoma.