Journal of AdvancedMedical and Dental Sciences Research

Background: The present study was conducted with the aim of comparing the haemodynamic variables and cost effectiveness between sevoflurane (inhalation) anaesthesia and propofol[total intravenous anaesthesia (TIVA)] based anaesthesia. Materials & methods: A total of 40 patients were enrolled. All the patients were randomly and broadly divided into two study groups as follows:Group 1: Sevoflurane group, and Group 2: Propofol group. All the patients were kept fasting overnight and were premedicated with Inj. Ranitidine 50 mg i.v in the pre operative room. All surgical procedures were carried out in all the patients according to their respective study groups. Both the Sevoflurane and Propofol infusion were stopped at the end of surgery when the skin sutures were being applied. Continuous monitoring of hemodynamic variables was seen. All the results were recorded in Microsoft excel sheet and were subjected to statistical analysis using SPSS software. Results: The intraoperative haemodynamic parameters consisting of heart rate and blood pressure were comparable between the two groups with no statistically significant difference. The recovery profile showed a significant difference as regards spontaneous eye opening which was 10.5 minutes in group 1 and 14.6 minutes in group 2. The Sevoflurane still costs more than the Propofol. The actual cost of Sevoflurane 50 ml bottle was about 820 rupees while the cost of same volume of Propofol was around 550 rupees. Conclusion: From the above results, the authors concluded the Sevoflurane costs more than the Propofol. However; hemodynamic effect of both is comparable.