Journal of AdvancedMedical and Dental Sciences Research

Introduction: The development of the inflammatory periapical lesion which results due to trauma from occlusion or pulpal necrosis causes a local response of bone around the apex of the tooth. Depending upon the nature of wound and available biological growth factors the outcome will be either regeneration or repair. Being a rich source of growth factors, platelet rich fibrin (PRF) possess many advantages in bone regeneration. The purpose of this studyis to evaluate the healing potential of the combination of PRF and Demineralized bone graft as opposed to using these materials alone. Materials and Methods: A periapical surgery was performed on thirteen patients with a large periapical inflammatory lesion and a large bony defect. Two study groups were made based on lottery method into Group A and Group B. The defects were then filled with a combination of PRF and Demineralized bone graft crystals in Group A and only Demineralized bone graft was used in Group B.Radiographically hard tissue fill (using standardized paralleling cone technique) were evaluated at baseline,1 month and 9 months postsurgery. Results: No differences in any of the investigated parameters were observed at baseline. At 6 months postsurgery, both groups showed significant improvement in clinical parameters (p< 0.001).PRF+DBM (Group A) was more effective than DBM (GroupB) alone as afavorable increase ofhard tissue fill was noted in group A compared with group B.On the basis of our outcome, we conclude the use of PRF in combination with Demineralized bone graft might have accelerated the bone regeneration in Group A as compared to Group B.