Journal of AdvancedMedical and Dental Sciences Research

Background: Perforated peptic ulcer is one of the most common surgical emergencies. Despite a definite association of H. pylori with peptic ulcer disease, its association with peptic ulcer perforation is still doubtful.The aims of study were Peptic perforation in reference to prevalence of H. pylori infection, age distribution of the patients with peptic perforation, sex distribution of H.pylori in peptic perforation, size and site of perforation, residential living of the patients. Method: The present study was conducted on 57 patients with clinical diagnosis of perforation of chronic peptic duodenal ulcer presenting emergency ward of M.L.B Medical College, Jhansi in Department of Surgery from May 2004 (retrospective study) and Feb. 2010 to Sep. 2011 (prospective study). Result: Commonest age of presentation of peptic perforation in Bundelkhand region was 30-60years (84.21%). 8.77% patients were belonging to poor economic status 84.21% were belonging to Middle Class and only 7.02% patients were belong to high class. Most of the patients (73%) were from poor socioeconomic status. According to study only 30% patients were chronic smoker. Most of the patients were non-alcoholic (73.68%). Most of the patients were active workers (85.96%), sedentary workers were few (14.04%). Most of thepatients (87.72%) were poorly educated. 89.47% of the patients were from rural areas. Most of the patients (82.46%) were normotensive. Only 1.75% patient was suffering from Ischemic heart disease. Almost all the patients (93%) were non Tubercular. Most of the patients (80.7%) were infected with H. pylori detected by biopsy urease test. Eradication therapy was effective in 97.8% of H. pylori positive patients. So eradication of H. pylori may reduce the recurrence of peptic perforation. Conclusion: It can be concluded that H. pylori may be the causative factor for perforation of peptic ulcer. In all factors studied H. pylori was most closely associated factor with perforated peptic ulcer. Eradication therapy was effective in 97.8% of H. pylori positive patients. So eradication of H. pylori may reduce the recurrence of peptic perforation