Journal of AdvancedMedical and Dental Sciences Research

Background: Insulin resistance (IR) is regarded as primary initiating factor for obesity, diabetes mellitus, dyslipidemia and cardiovascular disease (CVD) in adults. The present study was conducted to assess insulin resistance in young obese and its relation with smoking. Materials & Methods: 82 healthy subjects in the age group of 20–30 years of either gender were enrolled. Subjects were divided into two groups. Group I were smokers and group II were non-smokers. The subjects were divided according to their BMI (kg/ m2), as per ICMR guidelines. 5 ml of venous blood was collected in the fasting state. Serum insulin was estimated by sandwich ELISA technique. Insulin resistance was calculated by the formula— [HOMA-IR = FBG (mmol/L) 9 FPI (mIU/ml)/22.5. Results: Normal subjects were 70% in group I and 48% in group II, overweight 20% in group I and 20% in group II and obese in 10% in group I and 32% in group II. The mean HOMA-IR Index in group I as 1.78 and in group II was 1.62. The difference was non- significant (P> 0.05). Conclusion: Young smokers with obesity were prone to develop insulin resistance.