Journal of AdvancedMedical and Dental Sciences Research

Background: The present study was conducted to evaluate the postoperative analgesic efficacy of intraperitoneal 0.25% of ropivacaine with dexmedetomidine and 0.25% ropivacaine with nalbuphine and their role as postoperative analgesics. Materials & methods: 30 patients of either gender of age group between 20 – 55 years and ASA grade I and II undergoing elective laparoscopic cholecystectomy under general anaesthesia were enrolled in the study. All the patients were randomly allocated to one of the 3 groups of 10 each. In group 1, patients received 50ml solution having 49 ml of 0.25% ropivacaine with dexmedetomidine, Group 2 patients received 50 ml solution having 49 ml of 0.25% ropivacaine with nalbuphine, and group 3 patients received 50 ml solution having 0.25% ropivacaine with nalbuphine. Extubation was done after thorough oropharyngeal suctioning. The nasogastric tube was removed after recovery from anesthesia. Visual anlalog scale (VAS), which consists of 10 cm scale representing varying intensity of pain from 0 cm (no pain) to 10 cm (worst imaginable pain). Postoperative Postoperative pain was assessed using visual analog VAS score > 3 was managed with injection tramadol. Results: Mean VAS scores were lower in group 1 and significantly low at 3rd and 4th postoperative hour as compared to group 2 and group 3 (p value < 0.05). Thereafter, no significant difference was seen in VAS scores among all the three groups (p value > 0.05). In group 1, 50% patients required rescue analgesia whereas in group 2 90% and in group 3, 70% patients required rescue analgesia. This difference was statistically significant with p value < 0.05. In group 1, mean time to first dose of rescue analgesia was 7.79 hours whereas in group 2, it was 4.86 hours and in group 3, it was 4.21 hours which was statistically significant (p value < 0.05). Conclusion: Patients receiving 50ml solution having 49 ml of 0.25% ropivacaine with Dexmedetomidine demonstrated highest efficacy.