Journal of AdvancedMedical and Dental Sciences Research

Background: The relief of post- operative pain is a subject, which has been receiving an increasing amount of attention in the past few years. The present study was conducted to evaluate role of gabapentin as a pre-emptive analgesic in modified radical mastectomy. Materials & Methods: 60 adult female patients of ASA grade I and II diagnosed of Carcinoma Breast and posted for Modified Radical Mastectomy under general anesthesia were divided into 2 groups of 30 each. Group I patients received tab. Gabapentin 600mg orally with sips of water 1 hour before surgery and group II did not receive any drug before surgery. All the surgeries were done routine general anaesthesia with endotracheal intubation. Parameters such as sedation score and VAS was recorded and compared in both groups. Results: The mean age in group I was 47.2 years and in group II was 48.6 years. Mean weight in group I was 52.4 kgs and 53.1 kgs in group II. Duration of surgery was 1.8 hours in group I and 2.7 hours in group II. Duration of post- op analgesia was 5.2 hours in group I and 1.7 hours in group II. The mean VAS core in group I was 5.09 and in group II was 6.8. Mean sedation score in group I was 1.2 and in group II was 0.4. Common side effects was nausea/ vomiting seen in 6 in group I and 2 in group II, pruritis 1 in group I, headache 2 in group I and 1 in group II, constipation 1 in group I and urinary retention in 1 in group II. The difference was significant (P< 0.05). Conclusion: Pre-emptive tab. Gabapentin prolongs postoperative analgesia as compare to control group.