Journal of AdvancedMedical and Dental Sciences Research

Oral submucous fibrosis is a potentially malignant disorder predominantly seen in Central, Southern, and Southeast Asia. It is a collagen related disorder associated with betel quid chewing and characterized by progressive hyalinization of the submucosa. Majority of patients present with an intolerance to spicy food, rigidity of lip, tongue and palate leading to varying degrees of limitation of opening of the mouth and tongue movement.It can lead to squamous cell carcinoma.Oral submucous fibrosis is diagnosed based on clinical symptoms and confirmed by histopathology. Various treatment modalities includes drugs,local injections with chymotrypsin, hyaluronidase, dexamethasone and in advanced cases surgery.