Journal of AdvancedMedical and Dental Sciences Research

Background: Benign prostatic hyperplasia (BPH) is a common chronic progressive disease resulting in the enlargement of the prostate gland and bladder outlet obstruction in aging men. The present study was conducted to compare intrathecal dexmedetomidine with low-dose bupivacaine spinal anaesthesia versus a higher dose of bupivacaine in patients undergoing TURP. Materials & Methods: 50 patients of American Society of Anesthesiologists (ASA) Grade I–III undergoing TURP. Patients were divided into 2 groups of 25 each. Group I received 7.5 mg of 0.5% hyperbaric bupivacaine hydrochloride and group II received 3 µg of dexmedetomidine hydrochloride combined with 6 mg of 0.5% hyperbaric bupivacaine hydrochloride. Results: Time to reach T10 sensory block (min) was 12.3 in group I and 10.1 in group II. Modified Bromage score at the end of surgery 1 was seen in 4 in group I, 2 in 8 in group I and 14 in group II, 3 seen 13 in group I and 11 in group II. VAS score at 1 hours was 2.4 and 1.6, 2 hours was 3.1 and 2.4, 3 hours was 2.0 and 1.9 and 4 hours was 1.1 and 1.4. Common side effects was nausea seen in 3 in group I and 2 in group II, vomiting 2 in group I and 1 in group II, pruritis 4 in group I and 3 in group II and hypotension 1 in group I and 2 in group II. The difference was non- significant (P> 0.05). Conclusion: Addition of 3 µg of dexmedetomidine added to 6 mg bupivacaine produced a faster onset and longer duration of sensory and motor block as well as prolonged perioperative analgesia.