Journal of AdvancedMedical and Dental Sciences Research

Magnesium is the fourth most abundant cation in the body responsible for many biochemical reactions. It is also called as “nature’s physiologic calcium channel blocker”. Magnesium is an inorganic ion that has a non-competitive N-Methyl-D-Aspartate (NMDA) receptor antagonist property with antinociceptive effects in animals and human models. This antagonism reduces the induction and maintenance of central sensitization of nociceptive stimulation by altering pain processing. Seventy patients aged between 18yrs and 60yrs of physical status ASA grade 1 and ASA grade 2 undergoing elective infra umbilical surgeries were included in the study after ethical clearance from the college ethical committee. The mean duration of motor block in Magnesium sulphate group was 361.62±43.04 min and 208.29±27.38min in Normal saline group. Duration of motor blockade is more with MG group compared to NS group, which is statistically significant (p=<0.001)