Journal of AdvancedMedical and Dental Sciences Research

Background: Psoriasis is a common, disfiguring, and stigmatising skin disease. Adiponectin has been shown to exert anti-inflammatory, insulin-sensitizing and atheroprotective effect. The present study was undertaken for assessing plasma adiponectin levels in Psoriasis patients. Materials & methods: A total of 25 psoriasis patients and 25 healthy controls were enrolled. Complete demographic and clinical data of all the patients was obtained. Only patients with confirmed clinical and histopathological diagnosis of psoriasis were enrolled. Patients with history of any other systemic illness or any other co-morbid condition were excluded. Blood samples were obtained from all the patients and were sent to laboratory. Plasma adiponectin levels were measured. Results: Mean plasma adiponectin levels of the patients of the psoriasis group and control group was 8.12 µg/mL and 2.42 µg/mL respectively. On comparing statistically, it was seen that mean plasma adiponectin levels among the patients of the psoriasis group was significantly lower in comparison to the patients of the control group. Conclusion: Adiponectin levels are significantly lowered in psoriasis patients highlighting their role in the pathogenesis of the disease.