Journal of AdvancedMedical and Dental Sciences Research

Relevance of the research topic. The problem of preterm birth (PR) occupies one of the leading positions in terms of importance in modern obstetrics and neonatology, since they determine the level of perinatal and infant mortality and morbidity [59, 67, 68, 79]. Perinatal mortality among premature infants is much higher than among full-term infants. In 2015, complications of prematurity were the cause of death in 1 million cases [124]. Up to 70% of neonatal mortality and up to 75% of child mortality occur in premature babies [70]. Despite the close attention of scientists to this problem in recent years, the incidence of miscarriage remains high enough and does not tend to decrease [56]. In Russia, the incidence of preterm birth ranges from 7 to 12%, depending on the region.