Background: Unipolar (UP) and bipolar (BP) disorders differ in genetics, neurobiology, clinical course, treatment regimens and prognosis. The present study assessed clinical profile of BP and UP depression patients. Materials & Methods: This study was conducted on 78 patients of unipolar and bipolar depression of both genders. Clinical profile of patients was also recorded. The Hamilton Rating Scale for Depression-21 item (HAM-D) was used assessment of depression. Results: In unipolar depression, males were 25 and females were 20, in bipolar depression, males were 21 and females were 12. Age of onset in unipolar patients was 28.4 years and in bipolar patients was 22.5 years, total duration was 12.6 years in unipolar and 16.3 years in bipolar, number of episode was 3.5 in unipolar patients and 7.2 years in bipolar patients, number of hospitalizations was seen in 42 and 33 patients respectively and catatonic features were seen in 1 and 3 patients respectively. The difference was significant (P< 0.05). Suicidal thoughts were seen in 34 patients in unipolar and27 bipolar patients, anhedonia in 9 and 2 patients respectively, pseudodementia in 3 and 5 patients respectively, panic symptoms in 6 and 14 patients respectively, delusions in 8 and 25 patients respectively, auditory hallucinations in 10 and 16 patients respectively and first rank symptoms in 5 and 7 patients respectively. The difference was significant (P< 0.05). Conclusion: Authors found that unipolar and bipolar depression showed almost similar clinical features such anhedonia, pseudodementia, panic symptoms and delusions etc.
Key words: Anhedonia, Bipolar depression, Pseudodementia