Factor VII deficiency is a rare inherited autosomal recessive bleeding disorders, and is a chameleon disease that hides behind the wall of Hemorrhagic diseases of newborn that are usually Vit K dependent . The clinical phenotypes range from asymptomatic condition—even in homozygous subjects—to severe life-threatening bleedings (central nervous system, gastrointestinal bleeding) and hence presenting a case of a 9 day old neonate delivered at home who presented with oro nasal bleeds followed by seizures due a intra ventricular haemorrhage and chest X ray showing features of pulmonary haemorrhage. Child was initially treated symptomatically with blood transfusions, FFP and cryo- precipitate but did not improve until the factor VII values were sent and found to be deficient. Following which replacement therapy was given and all bleeding manifestations settled. Child later was followed up and found to be hemodynamically stable with adequate weight gain and no further bleeding manifestation.
Key words: Cryo- precipitate, Factor VII deficiency,
Received: 12 September 2018 Revised: 23 October 2018 Accepted: 25 October 2018
Corresponding Author: Dr. Padma Krishnan, Junior resident, Department of Pediatrics, MGM Hospital and Research Center, Kamothe, Navi Mumbai, Maharashtra, India
This article may be cited as: Krishnan P, Dabre L, Jatoo Z, Burli P. Factor VII deficiency in a Home Delivered Neonate. J Adv Med Dent Scie Res 2018;6(11):14-15.