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Volume 6 Issue 9 (September, 2018)

Original Articles

A Comparative Evaluation of Racemic Salbutamol and Levosalbutamol in Asthmatics
Vinay Sharma, Arshad Hasan

Background: Asthma is a chronic respiratory disease. The present study was conducted to compare racemic Salbutamol and Levosalbutamol in patients with asthma. Materials & Methods: The present study was conducted on 180 patients of both genders (males- 88, females- 92). All were divided into 2 groups of 90 each. Group I received 0.63 mg levosalbutamol and group II received 2.5mg salbutamol. Respiratory rate (RR), Heart rate (HR) oxygen saturation in room air (SPO2), PEFR (peak expiratory flow rate) & Serum K+ levels were recorded initially and after giving 3 nebulizations at 20 min. Results: Mean age was 45.24± 4.8 and 42.06± 3.6 in group I and group II respectively. The difference was non- significant (P> 0.05). Pre treatment respiratory rate (RR) was 28.32 and 27.45 in group I and group II respectively. Heart rate was 110.25 and 106.34 in group I and group II respectively. SPO2 was 96.37 and 96.75 in group I and group II respectively. PEFR was 194.31 and 195.29 in group I and group II respectively. Serum K level was 4.87 and 4.81 in group I and group II respectively. Asthma score was 7.7 and 9.32 in group I and group II respectively. The difference was non- significant (P> 0.05). Post treatment respiratory rate (RR) was 25.4 and 26.81 in group I and group II respectively. Heart rate was 112.35 and 125.21 in group I and group II respectively. SPO2 was 98.11 and 98.82 in group I and group II respectively. PEFR was 267 and 265 in group I and group II respectively. Serum K level was 4.41 and 3.52 in group I and group II respectively. Asthma score was 5.3 and 6.9 in group I and group II respectively. The difference was significant (P< 0.05). Conclusion: It was found that PEFR, SPO2 and asthma score was better with Levosalbutamol as compared to racemic Salbutamol.
Key words: Asthma, Levosalbutamol, Salbutamol.

Received:  20 April 2018                                        Revised: 26 June 2018                                           Accepted: 12 July 2018

Corresponding author: Dr. Arshad Hasan, Associate Professor, Department of Pharmacology, Rama Medical College Hapur, Uttar Pradesh, India

This article may be cited as: Hasan A, Pratik. A Comparative Evaluation of Racemic Salbutamol and Levosalbutamol in Asthmatics. J Adv Med Dent Scie Res 2018;6(9):1-4.

 
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