Background: The alterations in the circulatory cholesterol levels have been found to be associated with etiology of breast cancer and colorectal cancer. However, only a few reports are available on plasma lipid profile in head and neck cancer. Aim:To evaluate various lipid parameters in patients with oral leukoplakia. Materials and method: The study was conducted in the Department of Oral medicine of the dental institution. For the study group, we selected a total of 20 subjects ranging from 18 to 55 years diagnosed with oral leukoplakia which reported to the outpatient clinic of the department. For the evaluation of Total cholesterol, HDL and LDL 5 mL of blood was obtained from each patient. The blood was sent to the lab for evaluation. The obtained data was tabulated for further evaluation.Results: A total of 40 patients were included in the study, 20 in study group and 20 in control group. We observed that total cholesterol level in study group was 149.71 mg/dL and in control group was 189.64 mg/dL. Level of HDL in study group was 38.12 mg/dL and in control group was 46.89 mg/dL. The level of LDL in study group was 102.82 mg/dL and in control group was 122.39 mg/dL. Conclusion: Within the limitations of the study we conclude that plasma HDL, LDL and total cholesterol levels in patients with oral leukoplakia are slightly reduced and may act as a marker for diagnosing pre-cancerous conditions. Still further research is needed in this context.
Keywords: Oral leukoplakia, pre-cancerous, cholesterol, HDL.