Journal of AdvancedMedical and Dental Sciences Research

Background:Elevated homocysteine levels are thought to contribute to the development and progression of CVD through multiple mechanisms, including endothelial dysfunction, inflammation, oxidative stress, and promotion of atherogenesis. The present study was conducted to assess association between homocysteine and CVD. Materials & Methods:76 apparently healthy children aged 10 – 19 years of both genders were selected. Parameters such as residence (urban/rural), religion), birth weight, socioeconomic status and lifestyle factors, family history of vascular diseases, diet, serum triglycerides, serum cholesterol and serum high density lipoprotein (HDL) levels were recorded. Results: Out of 76 patients, males were 46 and females were 30. In subjects with Hyperhomocysteinemia and normal, residence was urban in 18 and 13 and rural in 22 and 25. Education was 0-5 years in 30 and 14 and >5 years in 10 and 23. Socioeconomic status was lower in 17and 5, middle in 13 and 8 and upper in 10 and 24 respectively. Type of diet was vegetarian in 25 and 9, non- vegetarian in 15 and 28. Diet folic acid (µgm/day) was <100 in 22 and 17 and >100 in 18 and 20. S. Triglyceride (mg %) <150 was seen in 16 and 15 and >150 in 24 and 22. S. Cholesterol (mg %) was <200 in 14 and 11 and >200 in 26 and 26. S. HDL <40 was seen in 8 and 22 and >40 in 32 and 15. Energy (Kcal)/day RDA in 13 and 25. Protein (gm)/day was RDA in 11and 24 subjects respectively. The difference was significant (P< 0.05). Conclusion: An association between hyperhomocysteinemia and low serum HDL levels and hypertriglyceridemia was found which are conventional risk factors for CVDs.