Journal of AdvancedMedical and Dental Sciences Research

Background: Casein-Phosphopeptide and Amorphous Calcium phosphate (CPP-ACP) is a popularized remneralizing agent available in various formulations and is supposed to help in remineralization. The aim of this study is to systematically review the literature to study the re-mineralizing potential of CPP-ACP in treating dental erosion. Materials &Methods: An electronic search of the literature in various sources like Pub Med, Science Direct, Cochrane Register of Controlled Trials (CENTRAL), Wiley online library, Google scholars, Ovid medicine, and Grey literature. Through the initial search, 164 articles related to the subject were identified. Out of those, 155 articles were excluded after screening and removing duplicates. Nine RCT’s were selected in which CPP-ACP were used as a treatment modality to treat or prevent dental erosion. Results: The results of these studies were not consistent as few trials claimed that the CPP-ACP has no significant effect on erosion. But recent studies show that there is increased precipitation of minerals and change in the surface hardness of enamel. Conclusions: The results of this review conclude that CPP-ACP is not a very potent re-mineralizing agent as it fails to reach the baseline hardness in the case of eroded enamel. Although it cannot repair dental erosion, CPP-ACP formulations can be used as a preventive measure or supplementary strategy in preventing dental erosion in susceptible individuals.