Journal of AdvancedMedical and Dental Sciences Research

Background:Approximately 90% of cases of diabetes are type-2, a bipolar condition marked by irregular production and reduced insulin action. The present study was conducted to assess serum testosterone levels in type II diabetic males and its relation with lipid profile. Materials & Methods:58 diabetic males and 58 healthy control subjects were subjected to assessment of waist-to-hip ratio and body mass index, serum fasting glucose, total cholesterol, triglycerides, HDL, and glycosated haemoglobin were made. Friedwald's algorithm was used to calculate LDL and VLDL levels. The ELISA microplate reader was used to estimate the levels of blood SHBG and serum total testosterone.Using serum total testosterone, SHBG, and albumin based on the Vermeulen's formula, the free testosterone calculator computed serum free testosterone. Results: The mean waist circumference (cm) was 84.2 and 76.4, WHR was 0.93 and 0.85, FBG (mg/dL) was 152.4 and 90.6, total cholesterol (mg/dL) was 194.2 and 152.4, HDL- cholesterol (mg/dL) was 39.1 and 41.5, LDL- cholesterol (mg/dL) was 124.2 and 90.4, VLDL- cholesterol (mg/dL) was 28.4 and 22.6, triglyceride (mg/dL) was 146.2 and 112.9, glycated haemoglobin (%) was 8.5 and 5.2, total testosterone (nmol/L) was 10.6 and 18.1, serum SHBG (nmol/L) was 40.3 and 62.4, and free testosterone (nmol/L) was 0.23 and 0.28 in group I and II respectively. The difference was significant (P< 0.05).TT≤8nmol/L was seen in 34 diabetic and 6 non- diabetic and FT≤0.225nmol/Ls in 26 diabetics and 8 non- diabetic subjects. The difference was significant (P< 0.05). Conclusion: Men’s blood sugar status and testosterone levels indicated a potential role for testosterone in the development of type 2 diabetes. Men with type 2 diabetes had considerably lower serum testosterone and SHBG levels.