Journal of AdvancedMedical and Dental Sciences Research

Background: Over the past 20 years, the prevalence of diabetes has increased significantly, from an estimated 30 million cases in 1985 to 285 million cases in 2010. The present study evaluated HOMA – IR in healthy subjects. Materials & Methods: 134 healthy subjects of both genders were selected. Assessment of blood pressure, weight and height and BMI were done. Fasting plasma insulin was determined by the electro chemiluminescence assay. HOMA – IR was calculated by the formula, HOMA – IR = fasting Glucose (mg/dl) X fasting plasma Insulin (µU/mL)/405. Results: Out of 134 subjects, males were 70 and females were 64. BMI was <18.5 kg/m2 in 52 and 18.5- 22.9 kg/m2 in 82 subjects. The difference was significant (P< 0.05). The mean FBS was 81.6 mg/dl, FPI was µU/mL, IR was 2.2, BMI was 19.4 kg/m2, SBP was 102.2 mm Hg and DBP was 75.4 mm Hg. There was positive correlation of HOMA – IR with age, BMI, SBP and DBP (P< 0.05). Conclusion: The mean HOMA-IR of Indians is higher than that of other populations. There exists a direct correlation between HOMA-IR and the risk factors for coronary artery disease. Early detection of severe insulin resistance can prevent many cases of type 2 diabetes mellitus and coronary artery disease.