Journal of AdvancedMedical and Dental Sciences Research

Background: Cirrhosis is the final stage attained by various chronic liver diseases after years or decades of slow progression. Cholinesterase is synthesized mainly in hepatocytes and is released into the blood. The present study was conducted for evaluating serum Cholinesterase levels in liver cirrhosis patients. Materials & methods:A total of 50 patients with cirrhosis of liver were enrolled. Complete demographic and clinical details of all the patients was obtained. Another set of 50 age- and gender-matched healthy subjects were enrolled as healthy controls. A Performa was made and complete medical profile of liver cirrhosis patients was recorded. Categorization of liver cirrhosis patients was done on the basis of severity according to Child Pugh score (CPS) as Grade A, Grade B and Grade C. Blood samples were obtained from all the patients and was sent to laboratory and serum cholinesterase levels were evaluated using an auto-analyzer. Results:Mean serum cholinesterase levels among patients of the study group and control group was 2123.3 IU/L and 7169.9 IU/L respectively. While comparing the serum cholinesterase levels among study group and control group, significant results were obtained. While correlating the serum cholinesterase levels among patients of the liver cirrhosis group with severity grading, significant results were obtained. Conclusion:Serum cholinesterase is useful both as a liver function test and in the assessment of liver cirrhosis.