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Volume 4 Issue 5 (September - October, 2016)

Original Articles

ASSESSMENT OF HOSPITAL ACQUIRED CLOSTRIDIUM DIFFICILE INFECTION IN PAEDIATRIC PATIENTS- A RETROSPECTIVE STUDY
Tribhuvanesh Yadav, Ashvini Kumar

Background: Clostridium difficile infection (CDI) is caused by Clostridium difficile is a gram-positive, spore-forming, anaerobic bacillus that can colonize the gastrointestinal tract.. CDI has a wide variation in severity, ranging from asymptomatic colonization to severe diarrhea, pseudomembranous colitis, toxic megacolon, bowel perforation and death. Incidence of CDI can be reduced by identification of potentially modifiable risk factors in vulnerable population. Hence; we evaluated the incidence and frequency of C. difficile along with its risk factors in a paediatric hospital. Materials & methods: The present study was conducted in the paediatric hospital and included 325 paediatric patients that were admitted who were diagnosed with diarrhoea and ICD (International Classification of Diseases) code for C. Difficile between June 2012 and July 2014. Demographic details of the patients with underlying diseases, implicated antibiotics, and length of antibiotic usage were noted. Additionally, the internal laboratory records for all CD-positive stools were reviewed. Adherence was pooled across periods and hand hygiene moments and was reported as a percentage of total hand hygiene opportunities. All the results were analyzed by SPSS software. Chi-square test and student t test were used for assessment of level of significance. Results: Mean age of the patients in the two study groups was 2.75 and 5.85 years respectively. Significant correlation was obtained while comparing the mean age of the paediatric patients, presence of underlying chronic disease and ICU stay. Significant correlation was obtained while comparing the solid organ tumour, congenital heart disease and oncology stay in between CDI and Non-CDI paediatric study groups. Conclusion: Importance of antibiotic programs is emphasized by prior antibiotic exposure which was found to be risk factor.
Key words: Clostridium difficile, Diarrhoea

Corresponding Author: Tribhuvanesh Yadav, Assistant Professor, Career institute of medical Sciences, Lucknow
 
This article may be cited as: Yadav T et al. Assessment of hospital acquired clostridium difficile infection in paediatric patients: A retrospective study. J Adv Med Dent Scie Res 2016;4(5):96-99.

 
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