Journal of AdvancedMedical and Dental Sciences Research

Background:To investigate and contrast the hemodynamic impacts of intravenous Magnesium sulfate versus Fentanyl citrate during surgical procedures conducted under general anesthesia.Methods:This prospective randomized study was carried out at our hospital, involving 120 ASA (American Society of Anesthesiologists) grade I or II patients, encompassing both genders and aged between 18 and 46 years. The participants were scheduled for elective surgeries, meeting the specified inclusion and exclusion criteria, and necessitating general anesthesia with endotracheal intubation. The subjects were randomly assigned to two groups, each consisting of 30 individuals. The F Group received Fentanyl citrate as the study drug, while the M Group received Magnesium sulfate. Results: In this prospective randomized study involving 120 ASA grade I or II patients, scheduled for elective surgeries requiring general anesthesia with endotracheal intubation, a comparison was made between two study groups—F Group, administered Fentanyl citrate, and M Group, administered Magnesium sulfate. The pulse rate in the F Group approached baseline values at 5 minutes post-intubation, while the M Group exhibited this trend at 10 minutes post-intubation. Significant differences were noted in hemodynamic parameters between the groups after the administration of study drugs. Notably, 5 minutes after the study drug, the M Group showed a significant fall in systolic blood pressure (1.39%), contrasting with the insignificant change in the F Group (0.03%). Conclusion:Magnesium sulfate demonstrates comparable intraoperative hemodynamic stability to Fentanyl citrate, though it does not exhibit superiority in this regard. Both substances contribute to maintaining stable hemodynamics during surgery, suggesting that Magnesium sulfate can be a viable alternative to Fentanyl citrate in providing intraoperative cardiovascular stability.