Journal of AdvancedMedical and Dental Sciences Research

Background: Skin adnexal tumors (SATs) comprise a diverse range of both benign and malignant tumors, showcasing differentiation towards various adnexal structures present in typical skin based on embryologic and histologic characteristics. These structures include eccrine, apocrine, follicular, and sebaceous components. Although the overall occurrence of SATs is relatively rare, their diagnosis can pose challenges. The primary objective of this study is to explore and analyze the spectrum of SATs, focusing on their microscopic features. Methods: A retrospective examination was carried out, encompassing all diagnosed cases of skin adnexal tumors (SAT). The study incorporated a total of 120 cases, and relevant clinical information was extracted from hospital medical records. Tissue biopsies, preserved in formalin, were processed into paraffin-embedded sections. Hematoxylin and eosin staining were then applied to these sections for the purpose of histopathological analysis. Results: Of the 120 cases examined, the majority (112/120) were identified as benign adnexal tumors, whereas (8/120) cases were diagnosed as malignant. The prevalence of skin adnexal tumors (SAT) was higher among females, particularly in the age group of 21–30 years (50/120). Sweat gland tumors comprised the largest subgroup, accounting for (50/120) cases, followed by hair follicle tumors (40/120). The head and neck region were the most commonly affected sites (80/120), with the face being the predominant location, followed by the trunk (30/120). Among the benign tumors, Hidradenoma papilliferum and Pilomatricoma each accounted for 24 cases, while sebaceous carcinoma emerged as the most prevalent malignant tumor (6/120). Conclusion: Skin adnexal tumors are relatively uncommon skin neoplasms. The head and neck region emerged as the most frequent site for these tumors, predominantly comprising benign cases. Hidradenoma papilliferum and pilomatricoma were identified as the most prevalent benign tumors in this category. Distinguishing between benign and malignant features through histopathology is crucial due to its significant implications for both therapeutic decisions and prognostic assessments.